Table 2.
Sex and age-adjusteda percentage differences (95% CI) in novel coronary heart disease (CHD) risk markers for lower socioeconomic position relative to the highest position (reference group).b
| Inflammatory and endothelial markers |
Pancreatic and adiposity markers |
||||||
|---|---|---|---|---|---|---|---|
| C-reactive protein |
Interleukin-6 |
E-selectin |
Tissue plasminogen activator |
Proinsulin |
Leptin |
Adiponectin |
|
| (N = 2063) | (N = 2049) | (N = 2049) | (N = 1795) | (N = 1795) | (N = 2053) | (N = 2051) | |
| Childhood | |||||||
| I and II | – | – | – | – | – | – | – |
| IIInm | 3.2 | 7.9 | 7.1 | 4.0 | 3.4 | 12.4 | −9.5 |
| (−8.5 to 14.8) | (−1.4 to 17.3) | (1.2–13.0) | (−4.6 to 12.5) | (−6.2 to 13.0) | (1.9–22.9) | (−18.1 to −0.9) | |
| IIIm | 22.6 | 20.5 | 7.1 | 6.8 | 19.9 | 22.6 | −11.8 |
| (12.0–33.2) | (12.0–29.0) | (1.8–12.5) | (−1.0 to 14.6) | (11.1–28.7) | (13.1–32.2) | (−19.7 to −3.9) | |
| IV and V | 25.1 | 17.6 | 8.0 | 4.9 | 19.1 | 21.9 | −10.9 |
| (14.2–36.1) | (8.8–26.4) | (2.4–13.5) | (−3.3 to 13.0) | (9.9–28.3) | (12.0–31.8) | (−19.0 to −2.7) | |
| Trend p | <0.001 | <0.001 | 0.002 | 0.171 | <0.001 | <0.001 | 0.013 |
| Early adulthood | |||||||
| I and II | – | – | – | – | – | – | – |
| IIInm | 13.8 | 8.9 | −1.7 | −2.0 | 4.1 | 16.2 | −2.6 |
| (3.8–23.8) | (0.8–16.9) | (−6.7 to 3.4) | (−9.3 to 5.4) | (−4.2 to 12.4) | (7.2–25.2) | (−10.0 to 4.9) | |
| IIIm | 16.2 | 7.7 | 1.7 | 5.7 | 17.8 | 12.3 | −9.8 |
| (5.1–27.3) | (−1.3 to 16.7) | (−4.0 to 7.3) | (−2.6 to 14.0) | (8.5–27.2) | (2.2–22.4) | (−18.1 to −1.6) | |
| IV and V | 36.2 | 22.3 | 5.4 | 2.5 | 16.8 | 13.5 | −3.1 |
| (23.8–48.7) | (12.3–32.3) | (−1.0 to 11.7) | (−6.8 to 11.8) | (6.2–27.3) | (2.3–24.8) | (−12.3 to 6.2) | |
| Trend p | <0.001 | <0.001 | 0.104 | 0.271 | <0.001 | 0.007 | 0.155 |
| Middle age | |||||||
| I and II | – | – | – | – | – | – | – |
| IIInm | 16.0 | 14.1 | −0.9 | 1.8 | 4.9 | 15.6 | 0.7 |
| (5.7–26.2) | (5.9–22.3) | (−6.1 to 4.3) | (−5.7 to 9.4) | (−3.7 to 13.4) | (5.4–26.8) | (−6.9 to 8.3) | |
| IIIm | 11.0 | 6.3 | 1.4 | 2.1 | 6.5 | 9 | −0.4 |
| (−0.5 to 22.5) | (−2.9 to 15.6) | (−4.4 to 7.3) | (−6.6 to 10.7) | (−3.3 to 16.3) | (−1.8 to 20.9) | (−8.9 to 8.2) | |
| IV and V | 26.6 | 15.2 | 1.2 | −7.6 | 7.6 | 12.7 | −3.0 |
| (14.4–38.8) | (5.4–25.1) | (−5.1 to 7.4) | (−16.9 to 1.6) | (−2.9 to 18.1) | (0.9–25.9) | (−12.2 to 6.1) | |
| Trend p | <0.001 | 0.002 | 0.579 | 0.355 | 0.035 | 0.090 | 0.386 |
a
Age at blood draw (60–64 years).
b
Socioeconomic position: I and II = professional and intermediate; IIInm = skilled non-manual; IIIm = skilled manual; IV and V = partly skilled or unskilled.