Table 4.
Selected life course social class model for each novel coronary heart disease (CHD) risk marker adjusted for sex, age a and potential mediators.
| Model 1 |
Model 2 |
Model 3 |
Model 4 |
Model 5 |
Model 6 |
|
|---|---|---|---|---|---|---|
| Sex and agea only | Current smoking (age 60–64) | Life course smoking (ages 20–53) | Current body mass index (age 60–64) | Life course body mass index (ages 4, 26 and 53) | All | |
| Childhood sensitive period model (manual vs non-manual social class in childhood) | ||||||
| Interleukin-6 (N = 1144) | 12.2 | 9.3 | 8.8 | 7.1 | 8.4 | 3.0 |
| (4.0–20.4) | (1.0–17.5) | (0.5–17.0) | (−1.0 to 15.2) | (0.2–16.6) | (−5.1 to 11.1) | |
| Leptin (N = 1147) | 16.7 | 18.4 | 15.6 | 0.6 | 4.8 | 2.4 |
| (7.6–25.9) | (9.2–27.6) | (6.4–24.9) | (−6.4 to 7.6) | (−3.0 to 12.5) | (−4.6 to 9.4) | |
| Childhood + early adulthood accumulation model (each additional time in manual vs non-manual social class) | ||||||
| C-reactive protein (N = 1151) | 16.3 | 13.8 | 13.6 | 11.3 | 13.5 | 8.2 |
| (9.6–23.0) | (6.9–20.6) | (6.7–20.5) | (4.7–17.8) | (6.8–20.2) | (1.4–15.0) | |
| E-selectin (N = 1144) | 2.4 | 2.4 | 1.5 | 0.3 | 1.0 | 0.0 |
| (−1.0 to 5.8) | (−1.1 to 5.9) | (−1.9 to 5.0) | (−3.0 to 3.7) | (−2.4 to 4.4) | (−3.5 to 3.5) | |
| Proinsulin (N = 1018) | 10.7 | 11.4 | 8.7 | 3.8 | 6.0 | 3.9 |
| (5.3–16.1) | (5.9–17.0) | (3.2–14.2) | (−1.0 to 8.6) | (1.1–11.0) | (−1.0 to 8.8) | |
a
Age at blood draw (60–64 years).