. 2014 Nov 2;27(1):84–97. doi: 10.1007/s12640-014-9497-5

Table 4.

Variants of histone H3 in humans

Variants	Name of genes	Genomic location (Ensembl)	Protein length (aa) (Swiss-Prot)	Function (references)
H3.1^a	HIST1H3A	6p22.2	136	Replication and DNA repair (Szenker et al. 2011)
	HIST1HAD
	HIST1H3C
	HIST1H3E
	HIST1H3I
	HIST1H3G
	HIST1HAJ
	HIST1H3H
	HIST1H3B
	HIST1H3F
H3.1t	HIST3H3	1p42.3	136	Chromatin reorganization during spermatogenesis (Witt et al. 1996)
H3.2^a	HIST2H3C	1q21.2	136	Replication and DNA repair (Szenker et al. 2011)
	HIST2H3A
	HIST2H3D
H3.3^b	H3F3A	1p42.2	136	Transcription activation (Mito et al. 2005)
H3.3^b	H3F3B	17q25.1	136	Transcription activation (Mito et al. 2005)
H3.3C (also named H3.5)	H3F3C	12p11.21	135	Transcription activation (Schenk et al. 2011)
H3.X^b	H3X	5p15.1		Protein not detected in vivo (Wiedemann et al. 2010)
H3.Y^b	H3Y	5p15.1		Probable regulation of cellular responses to stress, transcription activation (Wiedemann et al. 2010)
H3-like centromeric protein A (CENP-A)	CENPA	2p23.3	140	Proper chromosome segregation (Fukagawa 2004)

^aGene expressed in a replication-dependent manner

^bGene expressed in a replication-independent manner