Table II.

Ganglioside distribution in different brain regions of Rett (Mecp2^Bird and Mecp2^308/y) mice^a

	Concentration (μg lipid/100 mg dry weight)b
	Mecp2Bird (68 ± 2 days)						MeCP2308/y (321 ± 13 days)
	Cerebrum/Brainstem		Hippocampus		Cerebellum		Cerebrum/Brainstem		Cerebellum
	+/y	−/y	+/y	−/y	+/y	−/y	+/y	−/y	+/y	−/y
GM1	37.6 ± 1.9	35.2 ± 1.3	45.9 ± 1.5	41.2 ± 2.0	13.3 ± 0.4	12.2 ± 0.4	46.9 ± 3.4	51.3 ± 4.9	33.3 ± 4.6	33.5 ± 0.9
GD3	Trace	Trace	Trace	Trace	9.0 ± 1.4	10.8 ± 0.6	Trace	Trace	Trace	Trace
GD1a	149.2 ± 4.1	126.9 ± 3.2 *	176.8 ± 5.4	163.4 ± 5.5	44.2 ± 0.2	37.5 ± 2.7	130.9 ± 5.3	121.5 ± 5.6	42.4 ± 4.1	44.0 ± 2.3
GT1a/LD1	24.0 ± 0.8	24.0 ± 1.1	31.4 ± 2.8	31.4 ± 1.9	33.3 ± 1.2	28.2 ± 1.6	25.0 ± 0.9	22.3 ± 0.8	27.7 ± 2.6	29.9 ± 2.2
GD1b	52.3 ± 2.4	53.9 ± 1.8	51.1 ± 2.3	51.8 ± 2.1	25.1 ± 2.1	26.0 ± 0.6	44.9 ± 1.4	43.4 ± 1.9	21.8 ± 1.8	18.5 ± 1.0
GT1b	140.4 ± 3.6	134.1 ± 4.7	147.2 ± 8.5	154.8 ± 8.4	140.3 ± 5.6	131.6 ± 2.0	134.8 ± 5.1	131.7 ± 1.9	112.0 ± 6.7	112.0 ± 7.5
GQ1b	64.3 ± 1.3	66.1 ± 1.5	56.5 ± 6.2	64.2 ± 2.5	76.9 ± 1.5	77.1 ± 1.6	60.4 ± 0.7	58.8 ± 1.2	63.2 ± 2.4	55.8 ± 3.6

^aValues represent the mean±SE (n=3−4 independent samples). Asterisk indicates statistical significance where p<0.01 (two-tailed t-test).

^bDetermined from densitometric scanning of HPTLC plates, as shown in figure 1.