TABLE 1.
Initial Values and Bounds for Input Function Estimation.
| Parameter | Initial Value | Upper Bound | Lower Bound |
|---|---|---|---|
| K1 (min−1) | 0.89 | 2.0 | 0 |
| k2 (min−1) | 0.37 | 2.0 | 0 |
| k3 (min−1) | 0.17 | 0.5 | 0 |
| k4 (min−1) | 0.005 | 0.01 | 0 |
| fcc | 0.8 | 1.0 | 0.4 |
| fmc | 0.2 | 0.6 | 0 |
| fcm | 0.4 | 0.5 | 0 |
| fmm | 0.4 | 1.0 | 0.3 |
| A1 (MBq·mL−1) | 8.7 | 20.0 | 0 |
| A2 (MBq·mL−1) | 2.2 | 10.0 | 0 |
| A3a (MBq·min−1·mL−1) | 6,200.0 | 10,000.0 | 500.0 |
| l1 (min−1) | −5.2 | 0 | −15.0 |
| l2 (min−1) | −0.04 | 0 | −0.05 |
| l3 a (min−1) | −104.0 | 0 | −250.0 |
| t0 a (min) | 0 | 0.3 | 0 |
| w1 a | 1.0 | 3.0 | 0 |
| w2 a | 1.0 | 3.0 | 0 |
| w3 a | 0.1 | 0.1 | 0.05 |
a
Only for input function estimation using Fang and Muzic’s method (CWRU) [3].