Table 3.
Top SNPs at 7p12.2 associated with MaxDrinks with p-value < 10−7 in the SAGE sample
| SNP | BAND | BP | GENE | ALLE | P-meta | Q-meta | β-sa(SE) | P-sa | β-co(SE) | P-co |
|---|---|---|---|---|---|---|---|---|---|---|
| rs11575537 | 7p12.2 | 50499379 | DDC | A | 3.44E-05 | 0.0002 | 10.45(1.89) | 3.83E-08 | −2.73(2.94) | 3.52E-01 |
| rs11575549 | 7p12.2 | 50497671 | DDC | A | 3.49E-05 | 0.0002 | 10.45(1.89) | 3.83E-08 | −2.75(2.94) | 3.50E-01 |
| rs11575543 | 7p12.2 | 50498363 | DDC | T | 3.57E-05 | 0.0002 | 10.29(1.87) | 4.15E-08 | −2.62(2.89) | 3.64E-01 |
| rs11575542 | 7p12.2 | 50498481 | DDC | A | 4.17E-05 | 0.0002 | 10.24(1.87) | 5.13E-08 | −2.68(2.90) | 3.55E-01 |
| rs2190498 | 7p12.2 | 50657008 | GRB10 | C | 5.41E-05 | 0.0002 | 10.05(1.85) | 6.52E-08 | −3.09(2.93) | 2.93E-01 |
| rs11575302** | 7p12.2 | 50575188 | DDC | T | 2.87E-05 | 0.0002 | 10.14(1.87) | 6.71E-08 | −2.58(3.054) | 3.99E-01 |
| rs11575340* | 7p12.2 | 50563965 | DDC | A | 4.64E-05 | 0.0002 | 10.14(1.87) | 6.71E-08 | −2.73(2.93) | 3.52E-01 |
| rs930707 | 7p12.2 | 50587172 | DDC | A | 5.27E-05 | 0.0004 | 10.14(1.87) | 6.71E-08 | −3.05(2.97) | 3.05E-01 |
| rs11575522 | 7p12.2 | 50502889 | DDC | A | 4.45E-05 | 0.0003 | 10.03(1.86) | 7.79E-08 | −2.64(2.94) | 3.69E-01 |
Abbreviations: SNP, single-nucleotide polymorphism; BAND, gene band; BP, position is based on NCBI Genome Build 36.3; ALLE, minor allele; P-meta, p-value for meta-analysis; Q-meta, p-value for Cochrane’s Q statistic; β-co(SE), regression coefficient and standard error for the SAGE sample; P-sa, p-value for the SAGE sample; β-co(SE), regression coefficient and standard error for the COGA sample; P-co, p-value for the COGA sample.
*
The SNP is located at a transcription factor binding site;
**
The SNP is located at an exonic splicing silencer or an exonic splicing enhancer.