Figure 1. Bosutinib and dasatinib elevate IL-10 mRNA production and secretion in a dose-dependent manner.

Bone-marrow-derived macrophages were treated with the indicated concentrations of (A) bosutinib and (B) dasatinib for 1 h and then stimulated with LPS for 1 h. IL-10 mRNA levels were measured by qPCR (n=4, mean±S.E.M.). (C) Experiment was performed as above except culture supernatants were harvested after stimulation with LPS for 2 h. The concentration of IL-10 secreted into the culture medium was measured using the BIOPLEX system (n=4, mean±S.E.M.).