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. 2015 Jan 6;465(Pt 2):271–279. doi: 10.1042/BJ20141165

Figure 2. Bosutinib and dasatinib but not other protein tyrosine kinase inhibitors elevate IL-10 production in macrophages.

Figure 2

Bone-marrow-derived macrophages were treated with vehicle control or the indicated compounds for 1 h and then stimulated with LPS for (A) 1 h to induce mRNA expression or (B) 2 h for cytokine secretion. IL-10 mRNA levels were measured by qPCR, whereas the concentration of IL-10 secreted into the culture medium was measured using the BIOPLEX system (n=4, mean±S.E.M.). All compounds were used at 10 μM except HG-9-91-01, bosutinib and dasatinib which were used at 0.5, 3 and 0.3 μM respectively.