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. 2015 Jan 6;465(Pt 2):271–279. doi: 10.1042/BJ20141165

Figure 3. Bosutinib and dasatinib induce a gene expression programme directed by the transcription factor CREB.

Figure 3

Bone-marrow-derived macrophages were treated with vehicle control, 3 μM bosutinib or 0.3 μM dasatinib for 1 h and then stimulated with LPS for the indicated times. Expression of different CREB-dependent genes, (A) IL-10, (B) nurr77 and (C) c-FOS, were measured by qPCR. mRNA levels were normalized to 1 in unstimulated cells (mean±S.E.M., n=4).