Table 1.

Baseline Clinical Characteristics

	Weight Change
Variable	Lowest Tertile (n=128)	Middle Tertile (n=128)	Highest tertile (n=127)	P value
Age, (yrs), (median IQR)	56 (46–67)	55 (47–64)	58 (46–66)	0.645
Women	38%	25%	19%	0.003
Nonwhite	41%	37%	44%	0.486
Baseline weight, (kg) (median, IQR)	78 (62–96)	85 (73–97)	87 (76–106)	<0.001
Etiology of the heart failure
Ischemic	43%	50%	54%	0.209
Non-ischemic	56%	50%	46%
Hypertension	49%	43%	48%	0.654
Diabetes mellitus	30%	30%	37%	0.386
Current smoker	7.1%	10%	21%	0.047
Prior stroke	0%	0.8%	0%	1.000
Prior percutaneous coronary intervention	16%	23%	29%	0.035
Prior coronary artery bypass graft surgery	27	32	31	0.608
Heart rate, (bpm) (median, IQR)	80 (70–89)	80 (70–93)	84 (72–96)	0.029
Blood pressure, (mm Hg) (median, IQR)
Systolic	102 (90–116)	105 (94–117)	106 (95–117)	0.389
Diastolic	63 (58–70)	68 (60–73)	70 (60–76)	0.001
Orthopnea scale (0–4)	3 (3–4)	3 (3–4)	3 (3–4)	0.207
Jugular venous pressure >/=12 mm Hg	46%	46%	67%	0.001
Symptom score (global)	42 (30–60)	40 (30–60)	40 (20–60)	0.468
Left ventricular ejection fraction, (%) (median, IQR)	20 (15–25)	20 (15–23)	17 (15–20)	0.017
Serum sodium, (mEq/L) (median, IQR)	137 (135–139)	137 (136–140)	137 (134–140)	0.100
Blood Urea Nitrogen, (mg/dL) (median, IQR)	29 (20–49)	26 (17–35)	29 (19–41)	0.034
Serum creatinine, (mg/dL) (median, IQR)	1.4	1.3	1.3	0.107
Baseline Brain Natriuretic Peptide, (pg/mmol) (median, IQR)	428 (131–869)	463 (168–1132)	890 (389–1500)	<0.001
Peak VO2 (median, IQR)	9.9	10	7.9	<0.001
Six-minute walk, (ft) (median, IQR)	360 (0–700)	343 (0–830)	300 (0–632)	0.770
Beta-blocker prior to admission	70%	66%	51%	0.005
Angiotensin Converting Enzyme inhibitors or Angiotensin Receptor Blockers prior to admission	97%	98%	94%	0.183
Digoxin prior to admission	75%	77%	70%	0.401
Spironolactone prior to admission	48%	46%	40%	0.446