Table 1.

Examples of amidated conotoxins. Conceptual translation product of cDNA encoding conotoxins and the sequences of the corresponding mature conotoxins containing posttranslational modifications in addition to amidation. (γ = gamma-carboxy glutamate; O = 4-hydroxy proline; w = D-tryptophan).

Conotoxin	Primary translation product	Mature conotoxin
GI	MFTVFLLVVLATTVVSFPSERASDGRDDTAKDEGSDMEKLV EKKECCNPACGRHYSCGR	ECCNPACGRHYSC(NH2)a
AuIB	MFTVFLLVVLATTVVSFTSDRASDGRKDAASGLIALTMKGCCSYPPCFATNPDCGRRR	GCCSYPPCFATNPDC(NH2)b
SrIA	MGMRMMFTVFLLVVLATTVVSFTSDSAFDSRNVAANDKVSD MIALTARRTCCSRPTCRMEYPELCGGRR	RTCCSROTCRMγYPγLCG(NH2)c
GIIIA	MSKLGVLLTICLLLFPLTALPMDGDEPANRPVERMQDNISS EQYPLFEKRRDCCTPPKKCKDRQCKPQRCCAGR	RDCCTOOKKCKDRQCKOQRCCA(NH2)d
Conantokin G	MHLYTYLYLLVPLVTFHLILGTGTLDDGGALTERRSADATA LKAEPVLLQKSAARSTDDNGKDRLTQMKRILKQRGNKAR GEEEVQENQELIREKSNGKR	GEγγVQγNQγLIRγKSN(NH2)e
BuIIIA	MMSKLGVLLTICLLLFPLFALPQDGDQPADRPAERMQDDISSEQNSLLEKR VTDRCCKGKRECGRWCRDHSRCCGRR	VTDRCCKGKRECGRWCRDHSRCC(NH2)f
Contryphan M	MGKLTILVLVAAVLLSTQVMVQGDRDQPADRNAVPRDDNPGRARRKRMKVL NESECPWHPWCG	NγSγCPwHPWC(NH2)g
Gm5.2	MRCLPVFVILLLLIASAPSVDAQPKTKDDVPLAPLHDNIRS TLQTLRKKVCCRPVQDCCSGK	VCCRPVQDCCS(NH2)h
TxIXA	MHLSLARSAVLMLLLLFALGNFVVVQSGQITRDVDNGQLTDNRRNLQSKWKPVSLYMSRR GCNNSCQEHSDCESHCICTFRGCGAVNG	GCNNSCQγHSDCγSHCICTFRGCGAVN(NH2)i
TxX	MSGHTSVSFLLLSIVALGMVATVIC SCDSEFSSEFCERPEESCSCSTHTCCHWARRDQCMKPQRCISAQKGN GRRRLIHMQ	SCDSγFSSγFCγRPγγSCSCSTHTCCHWARRDQCMKPQRCISAQKGN(NH2)j

^aGray et al., 1981.

^bWatkins et al. (2004).

^cLópez-Vera et al. (2007).

^dCruz et al. (1985).

^eMcIntosh et al. (1984).

^fHolford et al. (2009).

^gHansson et al. (2004).

^hWalker et al. (1999).

ⁱLirazan et al. (2000).

^jBrown et al. (2005).