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. 2014 Mar 6;36(1):51–59. doi: 10.1093/eurheartj/ehu095

Figure 3.

Figure 3

SRT3025 increases hepatic Ldlr protein expression while decreasing plasma Pcsk9 in Apoe−/− mice. Eight week-old Apoe−/− mice were fed a high-cholesterol diet (1.25% w/w) supplemented with the Sirt1 activator SRT3025 (n = 9) or placebo (n = 9) for 12 weeks. (A) Relative mRNA expression levels of hepatic genes involved in cholesterol regulation. (B) Western blots of liver lysates for Ldlr, Pcsk9, and β-actin. (C) Plasma levels of Pcsk9. HCD, high-cholesterol diet; Pcsk9, proprotein convertase subtilisin/kexin type 9.