Figure 4.

Effect of anacetrapib, atorvastatin, and their combination on lesion composition. The number of monocytes adhering to the vascular endothelium per cross-section (A) was calculated. In the severe lesions (type IV and V), collagen content (B), and SMC content in the cap (C) were determined as stabilization factors and macrophage content (D) and necrotic content (E) were determined as destabilization factors, all as a percentage lesion area. The plaque stability index was calculated as the ratio of the stabilization factors to the destabilization factors (F). *P < 0.05, **P < 0.01, ***P < 0.001 when compared with control; ^##P < 0.01 when compared with atorvastatin. Data are presented as means ± SD (n = 15 per group).