Table 4.
Overall Adenoma Recurrence Percentages for Select Baseline Characteristics by Treatment Arm
| Baseline Characteristic |
Calcium Carbonate % (N/Total) (Arm Total: 95) |
Placebo % (N/Total) (Arm Total: 99) |
OR of Calcium Versus Placeboa |
95% CI for OR* | Treatment P Valuea |
Baseline Characteristics P Valueb |
|---|---|---|---|---|---|---|
| Site of Primary CRC | ||||||
| Colon | 45% (34/76) | 64% (51/80) | 0.473 | (0.266, 0.841) | 0.011 | 0.632 |
| Rectum | 42% (8/19) | 58% (11/19) | ||||
| Stage of Primary CRC | ||||||
| 0 | 57% (4/7) | 100% (4/4) | 0.462 | (0.258, 0.827) | 0.009 | 0.170 |
| I | 37% (19/51) | 59% (29/49) | ||||
| II | 51% (19/37) | 63% (29/46) | ||||
| Age | ||||||
| < 60 y | 42% (10/24) | 64% (18/28) | 0.472 | (0.265, 0.841) | 0.011 | 0.999 |
| ≥ 60 and < 70 y | 49% (16/33) | 58% (15/26) | ||||
| ≥ 70 y | 42% (16/38) | 64% (29/45) | ||||
| Sex | ||||||
| Female | 45% (17/38) | 62% (21/34) | 0.473 | (0.266, 0.841) | 0.011 | 0.978 |
| Male | 44% (25/57) | 63% (41/65) | ||||
| Adenomas Present | ||||||
| Yes | 53% (32/60) | 71% (42/59) | 0.437 | (0.241, 0.793) | 0.006 | 0.002 |
| No | 29% (10/35) | 50% (20/40) | ||||
| Synchronous Adenomas (SA) | ||||||
| ≥ 4 SAs | 75% (9/12) | 88% (14/16) | 0.448 | (0.245, 0.818) | 0.009 | 0.001 |
| 0–3 SAs | 40% (33/83) | 58% (48/83) |
Abbreviations: CI = confidence interval; CRC = colorectal cancer; OR = odds ratio.
a
Adjusted for baseline characteristic.
b
Adjusted for treatment arm.