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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Biol Blood Marrow Transplant. 2014 Sep 28;21(1):67–73. doi: 10.1016/j.bbmt.2014.09.019

Table 1.

IPS diagnostic criteria:

  1. Presence of widespread alveolar injury:
    1. Diffuse radiographic infiltrates on CXR or computed tomography (CT)
    2. SpO2 ≤ 93% on room air, or supplemental oxygen required to achieve SpO2 > 93%.
    3. Clinical signs and symptoms (cough, rales, dyspnea)
  2. Absence of lower respiratory tract infection, based upon BAL studies:
    1. Gram stain, fungal stain, acid fast bacilli (AFB) stain.
    2. Bacterial1, fungal, viral (RSV, parainfluenza, adenovirus, influenza A and B, CMV, rhinovirus) and mycobacterial cultures.
    3. Pneumocystis jiroveci assay (PCR, direct fluorescent antibody or cytology).
    4. Viral PCR assays for CMV, HSV, VZV, HHV-6 and community acquired respiratory viruses.2
    5. Galactomannan ELISA assay.2

  3. Absence of cardiac dysfunction, acute renal failure, or iatrogenic fluid overload.

Abbreviations: CXR, chest X Ray; CT, computed tomography; RSV, respiratory syncytial virus; HSV, herpes simplex virus; CMV, cytomegalovirus; PCR, polymerase chain reaction.

Key:

1

, quantitative bacterial culture ≥ 104 CFU/ml considered positive;

2

, per investigator discretion.