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. Author manuscript; available in PMC: 2015 Jan 7.
Published in final edited form as: Curr Top Dev Biol. 2010;92:73–129. doi: 10.1016/S0070-2153(10)92003-6

Fig. 1. Models for DSL ligand trans-activation and cis-inhibition in Notch signaling.

Fig. 1

Ligand expressed on the surface of the signal-sending cell binds to Notch expressed on the surface of the signal-receiving cell (trans-interactions) and induces sequential cleavages by A-Disintegrin-And-Metalloprotease (ADAM) and -secretase in Notch releasing the Notch intracellular domain (NICD) from the membrane. NICD translocates to the nucleus where it directly interacts with the CSL (CBF1, Su(H), LAG1) transcription factor and recruits coactivators to induce Notch target gene expression. Ligand binding to Notch expressed in the same cell (cis-interactions) prevents Notch activation by trans- ligand by competing with trans-ligand for Notch binding.