Table I.

Cellular factors that regulate DSL ligand expression

Effector of DSL ligand expression	DSL ligand	Effect on ligand expression: Upregulation (+) Downregulation (−)	Cell type	Biological effect	References
VEGFa	Dll4 b	+	Endothelial	Inhibition of angiogenic sprouting; arterial specification	Hellstrom et al., 2007; Liu et al., 2003; Lobov et al., 2007; Patel et al., 2005; Seo et al., 2006; Williams et al., 2006
TNFαc	Jagged1	+	Endothelial	Promotion of angiogenic sprouting	Benedito et al., 2009; Sainson et al., 2008
FGFd	Dll1b	+	Neural stem cells	Maintenance of spinal cord stem cells	Akai et al., 2005
LPSe	Dll4b	+	Dendritic cells	CD4+ Th1k polarization	Amsen et al., 2004
LPSe / PGE2f	Jagged1	+	Dendritic cells	CD4+ Th2k polarization	Amsen et al., 2004
IL6g	Jagged1	+	Mammary epithelial cells	Proliferation and invasion	Sansone et al., 2007; Studebaker et al., 2008
Hedgehog	Jagged1	+	Mesenchymal cells	Limb development	McGlinn et al., 2005
VEGFa+ FGF2d	Dll1b	+	Endothelial cells	Postnatal Arteriogenesis	Limbourg et al., 2007
Wnt	Jagged1	+	Hair follicle precortex	Hair follicle differentiation	Estrach et al., 2006
Wnt	Jagged1	+	Intestinal epithelial cells	Proliferation (tumorigenesis)	Rodilla et al., 2009; Pannequin et al., 2009
Wnt	Dll1b	+	Presomitic mesoderm	Somitogenesis	Hofmann et al., 2004
DERh and/or Heartless	Drosophila Delta	+	Embryonic mesoderm	Specification of muscle and heart progenitors, photo- receptor and non- neuronal cone cells	Carmena et al., 2002; Tsuda et al., 2002
TGFβi	Jagged1	+	Epithelial cells	Epithelial - mesenchymal transformation	Zavadil et al., 2004
FGF1d / FGF2d	Dll1b	-	Neuroepithelium	Maintenance of neuroepithelial precursors	Faux et al., 2001
PDGFi / angiotensin II	Jagged1	-	Vascular smooth muscle cells	Growth retardation	Campos et al., 2002
LPSe	Jagged1	-	Bone-marrow mesenchymal stem cells	Proliferation of CD4+ T cells	Liotta et al., 2008

Footnotes:

^aVascular Endothelial Growth Factor

^bDll: Delta-like

^cTumor Necrosis Factor α

^dFGF: Fibroblast Growth Factor

^eLipopolysaccharide

^fProstaglandin E2

^gInterleukin 6

^hDrosophila Epidermal Growth Factor Receptor

ⁱTransforming Growth Factor β

^jPlatelet-derived Growth Factor

^kTh: T helper cell