Skip to main content
. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Dig Dis Sci. 2014 Jul 29;60(1):86–100. doi: 10.1007/s10620-014-3307-z

Figure 3. Loss of KLF5 attenuates cellular proliferation in the adult intestine.

Figure 3

Figure 3

Figure 3

(A) Histological analysis for the comparison of cellular proliferation utilizing immunofluorescent staining for mitotic marker, phosphohistoneH3 (green) in wildtype and Klf5 loss-of-function mice (3, 5, 14, and 28 days post tamoxifen-induced recombination). Nuclear stain is DAPI (blue). (B) Quantification of average percentage of phosphohistoneH3 positive cells per crypt. Significance determined between groups of two (wildtype vs. loss of Klf5 for 3 days, wildtype vs. loss of Klf5 for 5 days, wildtype vs. loss of Klf5 for 14 days, wildtype vs. loss of Klf5 for 28 days, and loss of Klf5 for 3 vs. 28 days). (Mean ± SD, T-test: * P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, n = 3)