Table 2.

Relationship among smoking quantity, bilirubin levels and risk for lung cancer incidence in male participants the prospective cohort study

	Men (N=202,902)
	Total			Total bilirubin level (mg/dL)
				>1			0.75–1			<0.75
	No.	No. of incidence	HRa (95% CI)	No.	No. of incidence	HRa (95% CI)	No.	No. of incidence	HRa (95% CI)	No.	No. of incidence	HRa (95% CI)
Non-smoker	92,864	156	1 (Ref)	35,175	64	1 (Ref)	30,188	50	0.87 (0.59–1.27)	27,501	42	0.85 (0.56–1.27)
Total smokers	101,092	603	2.64 (2.19–3.18)	29,632	139	1.84 (1.35–2.51)	32,451	202	2.38 (1.77–3.19)	39,009	262	2.86 (2.15–3.81)
Pack-year
<30 pack-years	72,153	123	1.31 (1.02–1.69)	21,843	27	0.80 (0.50–1.29)	23,084	47	1.37 (0.92–2.03)	27,226	49	1.40 (0.94–2.07)
≥30 pack-years	24,146	454	4.01 (3.27–4.91)	6,269	108	3.14 (2.25–4.36)	7,777	145	3.48 (2.54–4.77)	10,100	201	4.14 (3.06–5.60)
# of Cigarettes per day
<10	31,520	106	1.55 (1.20–2.01)	10,602	23	0.96 (0.58–1.57)	10,270	37	1.39 (0.91–2.13)	10,648	46	1.85 (1.24–2.74)
10–19	38,866	261	2.71 (2.19–3.34)	11,031	62	1.97 (1.36–2.84)	12,557	91	2.58 (1.84–3.60)	15,278	108	2.70 (1.95–3.72)
≥20	26,879	221	4.29 (3.46–5.33)	6,759	52	3.39 (2.31–4.96)	8,374	70	3.72 (2.61–5.30)	11,746	99	4.32 (3.11–5.99)

^aAdjusted for age, educational level and body mass index