Table 3.

Relationship among smoking quantity, bilirubin levels and risk for lung cancer mortality in male participants the prospective cohort study

	Men (N = 202,902)
	Total			Total bilirubin level (mg/dL)
				>1			0.75–1			<0.75
	No.	No. of mortality	HRa (95% CI)	No.	No. of mortality	HRa (95% CI)	No.	No. of mortality	HRa (95% CI)	No.	No. of mortality	HRa (95% CI)
Non-smoker	92,864	98	1 (Ref)	35,175	36	1 (Ref)	30,188	34	1.04 (0.65–1.66)	27,501	28	0.99 (0.60–1.63)
Total smokers	101,092	478	3.24 (2.60–4.05)	29,632	104	2.39 (1.63–3.50)	32,451	165	3.28 (2.28–4.72)	39,009	209	3.96 (2.77–5.65)
Pack-year
<30 pack-years	72,153	90	1.62 (1.20–2.18)	21,843	14	0.80 (0.43–1.48)	23,084	39	2.08 (1.31–3.30)	27,226	37	2.01 (1.26–3.20)
≥30 pack-years	24,146	370	4.78 (3.77–6.05)	6,269	89	4.18 (2.81–6.22)	7,777	119	4.56 (3.11–6.69)	10,100	162	5.52 (3.81–7.99)
# of Cigarettes per day
<10	31,520	84	1.95 (1.45–2.62)	10,602	14	1.05 (0.56–1.94)	10,270	29	1.91 (1.17–3.14)	10,648	41	2.88 (1.83–4.52)
10–19	38,866	211	3.38 (2.65–4.32)	11,031	48	2.65 (1.71–4.09)	12,557	77	3.65 (2.45–5.45)	15,278	86	3.75 (2.53–5.55)
≥20	26,879	172	5.16 (4.01–6.65)	6,759	42	4.64 (2.96–7.27)	8,374	55	4.95 (3.24–7.57)	11,746	75	5.74 (3.85–8.56)

^aAdjusted for age, educational level and body mass index