Table 4.

Lung cancer incidence and mortality rates and adjusted HR per tertile of serum total bilirubin level among the male participants in the prospective cohort study by smoking status and smoking intensity

Characteristics	Men (N=202,902)
	No. of lung cancer incidence			Adjusted HRa (95% CI)			Incidence Rate Per 10 000 Person-Years (95% CI)
	Total bilirubin level (mg/dL)			Total bilirubin level (mg/dL)			Total bilirubin level (mg/dL)
	>1	0.75–1	<0.75	>1	0.75–1	<0.75	>1	0.75–1	<0.75
Total	215	270	324	1 (Ref)	1.24 (1.03–1.51)	1.52 (1.26–1.82)	4.27 (3.71–4.90)	5.79 (5.12–6.54)	6.93 (6.20–7.75)
Non-smoker	64	50	42	1 (Ref)	0.86 (0.59–1.27)	0.84 (0.56–1.26)	2.56 (1.98–3.30)	2.46 (1.86–3.27)	2.35 (1.72–3.22)
Total smokers	139	202	262	1 (Ref)	1.29 (1.03–1.62)	1.55 (1.25–1.92)	6.05 (5.09–7.18)	8.37 (7.27–9.64)	9.75 (8.61–11.03)
<30 pack-years	27	47	49	1 (Ref)	1.71 (1.04–2.79)	1.77 (1.09–2.89)	1.57 (1.06–2.33)	2.74 (2.05–3.67)	2.61 (1.95–3.48)
≥30 pack-years	108	145	201	1 (Ref)	1.10 (0.85–1.43)	1.31 (1.03–1.67)	22.41 (18.46–27.21)	24.85 (21.05–29.35)	27.79 (24.11–32.02)

	No. of lung cancer mortality			Adjusted HRa (95% CI)			Mortality Rate Per 10 000 Person-Years (95% CI)
	Total bilirubin level (mg/dL)			Total bilirubin level (mg/dL)			Total bilirubin level (mg/dL)
	>1	0.75–1	<0.75	>1	0.75–1	<0.75	>1	0.75–1	<0.75
Total	147	214	253	1 (Ref)	1.39 (1.12–1.72)	1.71 (1.39–2.10)	2.70 (2.30–3.17)	4.11 (3.59–4.69)	4.88 (4.32–5.52)
Non-smoker	36	34	28	1 (Ref)	1.03 (0.65–1.65)	0.98 (0.59–1.61)	1.34 (0.96–1.85)	1.49 (1.06–2.09)	1.43 (0.99–2.07)
Total smokers	104	165	209	1 (Ref)	1.37 (1.07–1.76)	1.66 (1.31–2.10)	4.18 (3.45–5.07)	6.17 (5.30–7.19)	7.02 (6.13–8.04)
<30 pack-years	14	39	37	1 (Ref)	2.60 (1.41–4.80)	2.56 (1.38–4.74)	0.77 (0.45–1.30)	2.06 (1.51–2.82)	1.80 (1.31–2.49)
≥30 pack-years	89	119	162	1 (Ref)	1.09 (0.82–1.44)	1.32 (1.01–1.71)	16.54 (13.44–20.36)	18.02 (15.06–21.57)	20.13 (17.26–23.48)

^*Adjusted for age, educational level and body mass index