Skip to main content
. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Biol Cell. 2014 Oct 13;107(1):1–21. doi: 10.1111/boc.201400043

Figure 1. Heterozygous knockout of the P2Y2R attenuates CD45+ microglial cell accumulation in the brains of TgCRND8 mice.

Figure 1

Microglial cell activation in the brains of 10-week-old TgCRND8 mice, and a non-transgenic littermate control (Tg−), TgCRND8 mice heterozygous for P2Y2R (Tg+P2Y2R+/−) and non-transgenic littermate control mice heterozygous for P2Y2R (Tg−P2Y2R+/−) were investigated by subjecting hippocampal brain sections to immunofluorescence analysis using anti-CD45 antibody (red) and Hoescht nuclear stain (blue). Results indicate a decrease in microglial cell accumulation in TgCRND8 mouse brain with deletion of the P2Y2R. Images are representative of results from 3 independent experiments and scale bar = 10 μm.