. Author manuscript; available in PMC: 2016 Jan 1.

Published in final edited form as: Biol Cell. 2014 Oct 13;107(1):1–21. doi: 10.1111/boc.201400043

Table 1.

Known agonists and antagonists of P2YRs

P2YR subtypes	Endogenous agonists	Synthetic agonists	Synthetic antagonists
P2Y₁R	ADP>ATP	2MeSADP, 2MeSATP, ATPγS, MRS2365	Suramin, RB2, MRS2179, MRS2279, MRS2365, MRS2500, A3P5PS, PPADS, BzATP
P2Y₂R	ATP=UTP	ATPγS, UTPγS, BzATP	Suramin, RB2
P2Y₄R	UTP (human) ATP (rat, mouse)	UTPγS	MRS2578, ATP (human), RB2 (rat), PPADS (weak), BzATP (rat)
P2Y₆R	UDP	UDPγS	Suramin, RB2, PPADS
P2Y₁₁R	ATP	BzATP, ADPγS	Suramin, RB2
P2Y₁₂R	ADP	2MeSADP, ADPγS	Suramin, RB2, ARC69931, ARC66096, MRS2395
P2Y₁₃R	ADP	2MeSADP, ADPγS	Suramin, RB2, PPADS, ARC69931, ARC66096, MRS2211
P2Y₁₄R	UDP-glucose

Abbreviations: 2MeSADP, 2-methylthio-adenosine 5′-diphosphate; 2MeSATP, 2-methylthio-adenosine 5′-triphosphate; ATPγS, adenosine 5′-(γ-thio)triphosphate; RB2, reactive blue 2; PPADS, pyridoxalphosphate-6-azophenyl-2′,4′-disulfonic acid; BzATP, 2′(3′)-O-(4-benzoylbenzoyl)adenosine 5′-triphosphate; UTPγS, uridine 5′-(γ-thio)triphosphate; UDPγS, uridine 5′-(γ-thio)diphosphate