Table 2.

Association between Coronary Flow Reserve, Luminal Angiographic Severity and Clinical Events.

Outcome	Univariable Model Hazard Ratio (95% CI)		Multivariable Model* Hazard Ratio (95% CI)
	CFR†	CADPI‡	CFR†	CADPI‡
Cardiovascular death or heart failure§	2.17 (1.34-3.52)	1.10 (0.99-1.21)	2.02 (1.20-3.40)	1.17 (1.01-1.34)
All-cause death or heart failure§	1.91 (1.29-2.83)	1.05 (0.97-1.15)	1.64 (1.08-2.48)	1.15 (1.03-1.29)
Cardiovascular death, heart failure§ or myocardial infarction¶	1.90 (1.23-2.93)	1.13 (1.03-1.24)	1.63 (1.02-2.59)	1.22 (1.08-1.38)

^*Includes pretest clinical score, left ventricular ejection fraction, left ventricular ischemia, revascularization with percutaneous coronary intervention or coronary artery bypass grafting within 90 days of noninvasive imaging, coronary flow reserve, and coronary artery disease prognostic index. There is a significant interaction between coronary flow reserve and revascularization with coronary artery bypass grafting, (P=0.04 for cardiovascular death or heart failure, P=0.006 for cardiovascular death, heart failure or myocardial infarction).

^†CFR denotes coronary flow reserve (per -1 unit).

^‡CADPI denotes coronary artery disease prognostic index (per +10 units).

^§Admission for heart failure.

^¶Admission for myocardial infarction.