Table 1.
Effects of dietary copper and iron deprivation on hematocrit, plasma ceruloplasmin, liver copper and ferritin iron. Data are Means ± SD for the N in parentheses.
Nutritional Copper or Iron Status |
|||
---|---|---|---|
Parameter | Deficient | Supplemented | Excess |
A. Rats on low copper diets | |||
Hematocrit (%) | 40 ± 6 (5) | 45 ± 6 (5) | -- |
Plasma ceruloplasmin (p-phenylene diamine oxidase activity) (nmol/min/mL) | 0.072 ± 0.008 (3)* | 0.125 ± 0.010 (3) | -- |
Liver copper (μg/g) | 2.1 ± 0.4 (4)* | 3.5 ± 0.9 (5) | -- |
B. Rats on low iron diets | |||
Hematocrit (%) | 14 ± 5 (6)* | 45 ± 6 (8) | 45 ± 5 (5) |
Liver ferritin Fe (μg/g) | 4 ± 4 (6)* | 31 ± 7 (8) | 100 ± 37 (5)* |
Liver copper (μg/g) | 11 ± 5 (4)° | 6 ± 2 (4) | 4 ± 1 (4) |
p < 0.025- <0.001 for difference from supplemented rats by Student’s t-test
p < 0.05 for difference from excess Fe treated rats