Table 2.
Summary of Mean FAc Concentrations in Ocular Tissues of Rabbits Treated with FAc Implant
| FAc concentration (ng/g) | |||
|---|---|---|---|
| Study day | 0.2 μg/day implant | 0.5 μg/day implant | 1.0 μg/day 2–0.5 μg/day implants |
| Aqueous humor | |||
| 2 | 0.0515 | 0 | 0 |
| 8 | 0 | 0 | 0.190 |
| 29 | 0.0985 | 0 | 0.188 |
| 55 | 0 | 0 | 0 |
| 89 | 0 | 0 | 0 |
| 182 | 0 | 0 | 0 |
| 271 | 0 | 0 | 0 |
| 363 | 0 | 0 | 0 |
| 539 | 0 | 0 | 0 |
| 728 | 0 | 0 | 0 |
| Vitreous humor | |||
| 2 | 1.26 | 5.75 | 35.9 |
| 8 | 0.988 | 5.06 | 18.5 |
| 29 | 0.507 | 3.20 | 5.40 |
| 55 | 1.02 | 2.34 | 4.39 |
| 89 | 0.261 | 1.52 | 2.65 |
| 182 | 0.367 | 1.41 | 1.70 |
| 271 | 0.127 | 0.362 | 1.26 |
| 363 | 0.176 | 8.51 | 13.6 |
| 539 | 0.0947 | 1.13 | 1.56 |
| 728 | 0.0398 | 0.546 | 1.23 |
| Lens | |||
| 2 | 4.21 | 23.2 | 27.9 |
| 8 | 3.45 | 24.8 | 154 |
| 29 | 5.03 | 18.9 | 25.2 |
| 55 | 18.8 | 24.4 | 52.5 |
| 89 | 2.32 | 11.2 | 23.3 |
| 182 | 2.59 | 14.8 | 12.7 |
| 271 | 2.51 | 4.15 | 11.2 |
| 363 | 2.78 | 45.8 | 604 |
| 539 | 3.55 | 39.7 | 48.4 |
| 728 | 1.33 | 9.61 | 58.9 |
| Retina | |||
| 2 | 12.2 | 40.5 | 142 |
| 8 | 8.66 | 23.0 | 125 |
| 29 | 5.06 | 21.3 | 22.6 |
| 55 | 8.71 | 15.1 | 30.3 |
| 89 | 0 | 11.6 | 13.5 |
| 182 | 4.80 | 9.38 | 0 |
| 271 | 0 | 9.84 | 5.75 |
| 363 | 0 | 66.9 | 69.3 |
| 539 | 0 | 12.0 | 38.2 |
| 728 | 0 | 0 | 6.18 |
| Choroid/PE | |||
| 2 | 63.9 | 59.4 | 136 |
| 8 | 42.2 | 89.3 | 169 |
| 29 | 35.4 | 66.6 | 173 |
| 55 | 22.8 | 41.9 | 124 |
| 89 | 9.45 | 38.8 | 67.6 |
| 182 | 12.2 | 25.4 | 57.5 |
| 271 | 8.14 | 17.2 | 37.7 |
| 363 | 5.93 | 82.2 | 161 |
| 539 | 2.80 | 22.8 | 87.2 |
| 728 | 3.15 | 12.1 | 23.5 |
| Iris/ciliary body | |||
| 2 | 24.2 | 36.2 | 81.5 |
| 8 | 27.1 | 17.0 | 114 |
| 29 | 7.83 | 28.0 | 78.4 |
| 55 | 20.6 | 11.9 | 49.0 |
| 89 | 3.05 | 10.3 | 15.9 |
| 182 | 15.5 | 14.7 | 27.5 |
| 271 | 4.95 | 4.02 | 5.95 |
| 363 | 3.05 | 26.3 | 27.2 |
| 539 | 1.73 | 6.95 | 16.3 |
| 728 | 0.563 | 3.31 | 8.50 |
PE, pigment epithelium.