Table 3.
Pharmacokinetic Parameters for FAc in Ocular Tissues Following Intravitreal Injection of FAc Implants
| Dose level (μg/day) | Ocular tissues | T1/2 (h) | Cmax (ng/g) | AUC(0–tlast) (ng*h/g) |
|---|---|---|---|---|
| 0.2 | Aqueous humor | a | 0.197 | |
| Vitreous humor | 4,404 | 1.35 | 4,008 | |
| Lens | 6,284 | 19.2 | 60,092 | |
| Retina | b | 12.2 | 22,673 | |
| Choroid/pigment epithelium | b | 63.9 | 153,323 | |
| lris/ciliary body | 4,003 | 30.6 | 98,238 | |
| 0.5 | Aqueous humor | a | a | a |
| Vitreous humor | 2,305 | 8.51 | 45,446 | |
| Lens | b | 52.4 | 440,154 | |
| Retina | a | 67.7 | 319,319 | |
| Choroid/pigment epithelium | 3,201 | 89.3 | 646,481 | |
| lris/ciliary body | 3,153 | 43.9 | 212,378 | |
| 1.0 | Aqueous humor | 1 | 0.377 | |
| Vitreous humor | 3,056 | 43.4 | 79,638 | |
| Lens | b | 154 | 731,686 | |
| Retina | 2,434 | 173 | 546,891 | |
| Choroid/pigment epithelium | 3,307 | 190 | 1,517,508 | |
| lris/ciliary body | 5,230 | 114 | 395,429 |
a
PK parameters not estimated due to samples being BLQ or the terminal phase could not be identified.
b
Values not reported because the AUC was extrapolated by more than 20% or R2 was <0.8.
PK, pharmacokinetic.