Figure 5.
Dynamic KDR channel modulation emerging from signaling activities is necessary to account for the dynamics of AngII-induced neuronal excitability. (A) Simulated fractions of unphosphorylated KDR channels for three scenarios describing AngII-mediated KDR channel phosphorylation: (1), a steady-state increase (2), a step-change increase, and (3), dynamic modulation. (B) AngII-induced firing rate responses (100 nM starting at t = 0 s) for the three simulated scenarios. (Inset) Distinct effects of dynamic phosphorylation corresponding to Scenario 3 as compared to those of nondynamic phosphorylation (Scenarios 1 and 2).