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. 2015 Jan 8;5:7689. doi: 10.1038/srep07689

Table 1. Chromosome structural aberrations (CSA) in first-cleavage (1-Cl) zygotes after exposure of male mice to 7.5 mg/kg MLP.

						DAPI Analysis^c		PAINT Analysis^c
Treatment day^a	No of. mice^b	Stage at treatment	No. of zygotes analyzed	No. of zygotes with CSA	% ± S.E.	Chromosome-type	Chromatid-type	Cell equivalents	Total
Controls	45 (91)		282	3	1.1 ± 0.6	0.014 ± 0.008	0	166	0.018 ± 0.016
3	30 (60^*)	Epidydimal sperm	139	15	10.8 ± 0.6^*	0.237 ± 0.153	0.007 ± 0.008	82	0.219 ± 0.096
7	53 (57^*)	Testicular sperm	230	41	17.8 ± 2.0^#	0.426 ± 0.124	0.004 ± 0.005	135	0.488 ± 0.179
23	52 (81)	Diplotene spermatocytes	293	188	64.2 ± 3.8^#	1.683 ± 0.158	0.007 ± 0.007	170	1.929 ± 0.207
37	27 (89)	Dividing spermatogonia	216	12	5.6 ± 1.1^§	0.093 ± 0.008	0	127	0.064 ± 0.013
49	37 (92)	Stem cells	167	2	1.2 ± 0.6	0.006 ± 0.007	0.006 ± 0.005	93	0

^aPrior to mating.

^bPercent of matings in parenthesis.

^cNumber of CSA per metaphase (mean ± Standard Error).

*p < 0.001 versus controls (Chi-square).

^#p < 0.0001 versus controls (Chi-square).

^§p < 0.05 versus controls (Chi-square).