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. Author manuscript; available in PMC: 2015 Jan 8.
Published in final edited form as: Chem Sci. 2011 May 16;2(8):1606–1610. doi: 10.1039/C1SC00235J

Table 2.

Pyridone Scope

graphic file with name nihms640993u2.jpg
Entry Product Cp* b Cpt c
1 graphic file with name nihms640993t1.jpg
3a 		90% (6:1) 86% (14:1)
2 graphic file with name nihms640993t2.jpg
3b 		85 % (5:1) 78% (15:1)
3 graphic file with name nihms640993t3.jpg
3c 		76% (>19:1) -
4 graphic file with name nihms640993t4.jpg
3d 		98 % (5:1) 98% (8.3:1)
5 graphic file with name nihms640993t5.jpg
3e 		85 % (3.3:1) 82% (4.8:1)
6 graphic file with name nihms640993t6.jpg
3f 		75% (3.6:1) 69% (4.6:1)
7 graphic file with name nihms640993t7.jpg
3g 		60% (3.8:1) 82% (4.6:1)
8 graphic file with name nihms640993t8.jpg
3h 		- 85% (>19:1)
9 graphic file with name nihms640993t9.jpg
3i 		75% (6.8:1) 65% (>19:1)
10 graphic file with name nihms640993t10.jpg
3j 		74% (>19:1) 78% (8.1:1)
11d graphic file with name nihms640993t11.jpg
3k 		85% (>19:1) -
12 graphic file with name nihms640993t12.jpg
3l 		85 % (>19:1) -
13e graphic file with name nihms640993t13.jpg
3m 		62 % (4.7:1) 50% (>19:1)
14 graphic file with name nihms640993t14.jpg
3n 		78% (11:1) -
15 graphic file with name nihms640993t15.jpg
3o 		65% (2.5:1) 58% (4.8:1)
16 graphic file with name nihms640993t16.jpg
3p 		69% (2.1:1) 56% (7.2:1)
17 graphic file with name nihms640993t17.jpg
3q 		77% (5:1) 81 % (12.3:1)
18 graphic file with name nihms640993t18.jpg
3r 		60 % (4.8:1) 79% (16:1)
19 graphic file with name nihms640993t19.jpg
3s 		74% (11:1) -
20 graphic file with name nihms640993t20.jpg
3t 		52% (1.2:1) 60% (1:1.2)
21d graphic file with name nihms640993t21.jpg
3u 		53% (5.8:1) 55% (2.7:1)
a

Conditions: 1 (1 equiv), alkyne (1.1 equiv), rhodium catalyst, Cu(OAc)2•H2O in DCE at 80 °C.

b

Cp*= Rh(C5Me5)(MeCN)3(SbF6)2.

c

Cpt = Rh(C5H3(t-Bu)2)(MeCN)3(SbF6)2.

d

10 mol % rhodium catalyst.

e

2 equiv alkyne.