Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Optimization for Large Scale Reactions
| |||||
|---|---|---|---|---|---|
| Entry | Scale (mmol) | Catalyst (mol %) | Conc. (M) | Cu(OAc)2•H2O (mol %) | GC/MS yield (%) |
| 1 | .22 | 5 | 0.3 | 20 | 86 |
| 2 | .22 | 1 | 0.3 | 20 | 15 |
| 3a | .22 | 1 | 0.3 | 20 | 37 |
| 4a | .22 | 2.5 | 0.15 | 20 | 35 |
| 5a | .44 | 1 | 0.6 | 20 | 45 |
| 6a | 6.22 | 2 | 0.6 | 20 | 69b |
| 7c | .22 | 5 | .3 | 0 | 40 |
Portionwise addition of alkyne; see SI.
Isolated yield.
Reaction conducted under O2 in presence of NaOAc (4 equiv).
