Associations of SNPs related to vitamin D metabolism with circulating concentrations of 25(OH)D (A) and risk of type 2 diabetes (B)
For analysis of 25-hydroxyvitamin D (25[OH]D), summary estimates were obtained from adults without diabetes from two studies, Ely16 and EPIC-Norfolk.4 For analysis of type 2 diabetes, summary estimates were obtained from four case-control studies (Cambridgeshire,15 ADDITION-Ely,19, 20 Norfolk Diabetes,15 and DIAGRAM18) and one case-cohort study (EPIC-InterAct17). SNPs=single nucleotide polymorphisms.