Fig. 13.
Massion Trichrome staining (undecalsified hard tissue sections at week 4, 8 and 12,) and hematoxylin and eosin (H&E) staining (decaclfied section at week 4) of iCMBA/HA and control groups. After the fast degradation of iCMBA/HA composites, hydroxyapatite particles were scattered around and consequently incorporated into the new bone formation, Thicker cortical bone with more organized microstructure were observed in iCMBA/HA group compared to control group (Massion Trichrome staining, 40X). Comparing to control group, parallel new vessel fomation was observed in iCMBA/HA group after 4 weeks of injection, indicates no inhibiting effect on neovasculation from iCMBA/HA (H&E staining, 40X). T: fibrous tissue; B: bone ; HA: hydroxyapatite particle; BM: Bone marrow cavity.