Table 3.
Clinicopathological features, H. pylori and EBV infection in gastric tumors
| Variable | H. pylori | CagA | EBV | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Negative | Positive | p-value | Negative c | Positive | p-value | Negative | Positive | p-value | |
| Age (Median ± IQR) | 57 ± 25 | 64 ± 16.75 | 0.027* | 57 ± 22 | 64.5 ± 16.5 | 0.027* | 63 ± 20 | 67 ± 21.5 | 0.192 |
| Gender [N(%)] | |||||||||
| Female | 9 (22.5) | 31 (77.5) | 0.023*a | 15 (37.5) | 25 (62.5) | 0.307a | 39 (97.5) | 1 (2.5) | 0.115a |
| Male | 6 (7.1) | 79 (92.9) | 26 (30.6) | 59 (69.4) | 74 (87.1) | 11 (12.9) | |||
| Tumor location [N(%)] | |||||||||
| Non-cardia | 12 (16.4) | 61 (83.6) | 0.080b | 26 (35.6) | 47 (64.4) | 0.519b | 67 (91.8) | 6 (8.2) | 0.592b |
| Cardia | 3 (5.8) | 49 (94.2) | 15 (28.8) | 37 (71.2) | 46 (88.5) | 6 (11.5) | |||
| Histological subtype [N(%)] | |||||||||
| Intestinal-type | 6 (8.5) | 65 (91.5) | 0.247b | 25 (46.3) | 29 (53.7) | 0.012*b | 63(88.7) | 8 (11.3) | 0.650b |
| Diffuse-type | 9 (16.7) | 45 (83.3) | 16 (22.5) | 55 (77.5) | 50 (92.6 | 4 (7.4) | |||
| Stage [N(%)] | |||||||||
| Early | 7 (15.9) | 37 (84.1) | 0.680b | 25 (56.8) | 19 (43.2) | 0.000*b | 41 (93.2) | 3 (6.8) | 0.999b |
| Advanced | 6 (8.3) | 66 (91.7) | 14 (19.4) | 58 (80.6) | 64 (88.9) | 8 (11.1) | |||
| Tumor invasion [N(%)] | |||||||||
| T1/T2 | 4 (13.3) | 26 (86.7) | 0.453b | 13 (43.3) | 17 (56.7) | 0.616b | 29 (96.7) | 1 (3.3) | 0.560b |
| T3/T4 | 11 (11.6) | 84 (88.4) | 28 (29.5) | 67 (70.5) | 84 (88.4) | 11 (11.6) | |||
| Lymph node metastasis [N(%)] | |||||||||
| Absent | 3 (25) | 9 (75.0) | 0.193b | 8 (66.7) | 4 (33.3) | 0.024*b | 12 (100) | 0(0) | 0.999b |
| Present | 12 (10.6) | 101 (89.4) | 33 (29.2) | 80 (70.8) | 101 (89.4) | 12 (10.6) | |||
| Distant metastasis [N(%)] | |||||||||
| Absent | 11 (16.7) | 55 (83.3) | 0.136b | 30 (45.5) | 36 (54.5) | 0.005*b | 62 (93.9) | 4 (6.1) | 0.258b |
| Present | 4 (6.8) | 55 (93.2) | 11 (18.6) | 48 (81.4) | 51 (86.4) | 8 (13.6) | |||
| EBV infection [N(%)] | |||||||||
| Absent | 15 (13.3) | 98 (86.7) | 0.998b | 39 (34.5) | 74 (65.5) | 0.358b | |||
| Present | 0 (0) | 12 (100) | 2 (16.7) | 10 (83.3) | |||||
*Significant difference between groups, p < 0.05. ap value after adjustment for age; bp value after adjustment for age and gender; cNegative samples for H. pylori and samples with H. pylori infection but without CagA virulence factor; EBV: Epstein-Barr virus; IQR: interquartile range.