Table 3.
Cytokine Laboratory Responses for Suspected Lassa Patients
| Cytokine | LF (n=25)a | LPE (n=19)b | NLFI (n=9)c | p-Valued |
|---|---|---|---|---|
| IFN-gamma | 871.16 (0.00, 2007.24) | 0.00 (0.00, 0.00) | 0.00 (0.00, 0.00) | 0.0005* |
| Fatal | 1181.59 (625.21, 2547.12) | 0.00 (0.00, 1763.33) | 0.00 (0.00, 0.00) | 0.0454* |
| Nonfatal | 0.00 (0.00, 1036.89) | 0.00 (0.00, 0.00) | 0.00 (0.00, 0.00) | 0.1409 |
| IL-10 | 68.41 (0.00, 385.12) | 19.82 (7.56, 87.55) | 14.01 (0.00, 91.13) | 0.7542 |
| Fatal | 151.56 (0.00, 1232.97) | 484.85 (70.14, 1838.94) | 244.06 (91.13, 396.99) | 0.7233 |
| Nonfatal | 58.08 (0.00, 383.35) | 18.14 (0.00, 34.94) | 0.00 (0.00, 22.68) | 0.5492 |
| IL-8 | 663.00 (270.49, 1399.42) | 501.95 (125.81, 1624.92) | 133.39 (32.62, 282.90) | 0.1055 |
| Fatal | 1397.16 (821.32, 1750.38) | 1339.71 (704.54, 2073.66) | 270.02 (119.11, 420.92) | 0.1394 |
| Nonfatal | 353.29 (101.57, 522.17) | 414.65 (124.91, 1624.92) | 133.39 (16.38, 282.90) | 0.3349 |
| IL-6 | 281.01 (20.29, 928.19) | 40.56 (0.00, 1213.77) | 0.00 (0.00, 0.00) | 0.0523 |
| Fatal | 938.84 (717.56, 1174.01) | 1579.19 (646.83, 2989.08) | 2027.68 (0.00, 4055.36) | 0.7255 |
| Nonfatal | 20.29 (0.00, 108.90) | 38.40 (0.00, 102.90) | 0.00 (0.00, 0.00) | 0.1144 |
| IL-1beta | 0.00 (0.00, 0.00) | 0.00 (0.00, 103.05) | 0.00 (0.00, 0.00) | 0.0133* |
| Fatal | 0.00 (0.00, 0.00) | 70.63 (0.00, 436.28) | 0.00 (0.00, 0.00) | 0.2466 |
| Nonfatal | 0.00 (0.00, 0.00) | 0.00 (0.00, 58.79) | 0.00 (0.00, 0.00) | 0.0235* |
Values are expressed as median (interquartile range).
a
LF defined as PCR+(or Ag+when PCR data were unavailable).
b
LPE defined as PCR–IgM+(or Ag–IgM+when PCR data were unavailable).
c
NLFI defined as PCR–IgM– (or Ag–IgM– when PCR data were unavailable).
d
p-Value for Kruskal–Wallis one-way ANOVA test for comparing median values among the three comparison groups.
*
p<0.05.