Table 4.
Baselinea | After free drugb | p-valuec | After LNPb | p-valuec | |
---|---|---|---|---|---|
WBC (thousands/μl) | 10.1±4.3 | 8.6±1.9 | 0.92 | 11.7±3.6 | 0.93 |
Platelet (thousands/μl) | 496±102 | 576±125 | 0.04 | 636±117 | 0.10 |
Total complement (U/ml) | 129±73 | 146±76 | 0.31 | 139±59 | 0.76 |
C-Reactive protein (mg/liter) | 0.2±0.0 | <0.2±0.0 | 1.00 | <0.2±0.0 | 0.39 |
Cholesterol (mg/dl) | 162±16 | 162±24 | 0.80 | 191±15 | 0.07 |
To establish a baseline, blood was collected at least 7 days prior to drug administration.
Blood was collected 7 days after drug administration.
p-value was determined by paired two-tailed Student's t-test.
Venous blood samples were analyzed for complete blood count, serum chemistry, total complement, and C-reactive protein. Values are expressed as mean±standard deviation. No parameters excluded from this table showed a postadministration increase to a value outside of the reference range in any primates (n=4).