. 2015 Jan 1;31(1):107–114. doi: 10.1089/aid.2014.0210

Table 4.

Changes in Selected Inflammatory Indicators and Cholesterol After Subcutaneous Administration of Lopinavir, Ritonavir, and Tenofovir in Free or Anti-HIV Lipid Nanoparticle Form

	Baseline^a	After free drug^b	p-value^c	After LNP^b	p-value^c
WBC (thousands/μl)	10.1±4.3	8.6±1.9	0.92	11.7±3.6	0.93
Platelet (thousands/μl)	496±102	576±125	0.04	636±117	0.10
Total complement (U/ml)	129±73	146±76	0.31	139±59	0.76
C-Reactive protein (mg/liter)	0.2±0.0	<0.2±0.0	1.00	<0.2±0.0	0.39
Cholesterol (mg/dl)	162±16	162±24	0.80	191±15	0.07

^{^a}

To establish a baseline, blood was collected at least 7 days prior to drug administration.

^{^b}

Blood was collected 7 days after drug administration.

^{^c}

p-value was determined by paired two-tailed Student's t-test.

Venous blood samples were analyzed for complete blood count, serum chemistry, total complement, and C-reactive protein. Values are expressed as mean±standard deviation. No parameters excluded from this table showed a postadministration increase to a value outside of the reference range in any primates (n=4).