Table 2.

Meaning of HIV Infection and Perception of an HIV Cure

	Meaning of HIV infection	Perception of HIV cure
Patient–society	PWID view themselves as inferiors or social outcasts. Family and peer groups are protective against stigma and central to HIV care including medication adherence and emotional well-being. New peer support groups are established based on HIV or drug use, forming a new collective identity.	The possibility of being cured of HIV inspires hope among PWID with the possibility of reintegration into society. The curability of HIV would decrease fatalistic attitudes toward the disease and may reduce fear and stigma. Curing HIV may not change a patient's identity as a formerly HIV-infected individual.
Patient–health system	HIV is an important national health priority with free comprehensive care and treatment for those who seek it. Many HIV-infected PWID remain outside of care due to stigma and other barriers. Methadone is an important point of entry to care for PWID.	Increased testing uptake and linkage to care may be a positive unintended consequence of cure research. PWID believe they will not have access to a cure even if it were available due to financial and other structural barriers.
Patient–physician	HIV specialist physicians establish relationships with their patients in a primary care-like model. Long-term physician–patient relationships increase trust and adherence. However, HIV-associated stigma is prevalent.	HIV cure may be a less desirable intervention when compared to ART, which is free, low risk, and highly effective.