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Number of studies of each intervention type by epoch. The recruitment year variable was divided into four epochs: pre-combination antiretroviral therapy (cART) (up to and including 1995), triple cART (1996–2002), multi-cART (2003–2008), and post-Berlin patient (2009–present). The most recent epoch was not included in this analysis as there were too few studies included in this review. *p<0.05, **p<0.007.
