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. Author manuscript; available in PMC: 2015 Jan 8.
Published in final edited form as: Am J Transplant. 2013 Sep 5;13(11):3021–3030. doi: 10.1111/ajt.12417

Figure 6. Fc-Silent Anti-CD154 dAbs results in iTreg generation even in the presence of CTLA4-Ig.

Figure 6

(A) Representative flow plots of total CD4+ T cells (top panels) and antigen-specific CD4+ (Thy1.1+) T cells (bottom panels) in draining lymph nodes at day 11, with gates on CD25+ Foxp3+ cells. (B) Percentages of CD25+ Foxp3+ cells within the total CD4+ T cell compartment and the antigen-specific CD4+ T cell compartment. (C) Representative flow plots of Helios expression on total CD4+ T cells (left panel), as well as on total endogenous CD4+ CD25+ Foxp3+ Treg (upper right panels) and antigen-specific Thy1.1+ iTreg (lower right panels). Data are cumulative of four separate experiments with a total of ten to fourteen mice per group. * p < 0.05, ** p < 0.01, *** p < 0.001.