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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Cell Metab. 2014 Apr 10;20(1):10–25. doi: 10.1016/j.cmet.2014.03.002

Figure 2. AMPK Signaling and Aging Pathways.

Figure 2

AMPK sits upstream of multiple signal transduction pathways known to modulate the aging process. Lines represent direct signaling effects. Color of line reflects effect on target – green equals activating, red equals inhibiting. Color of modification equals effect of modification – green equals activating, red equals inhibiting. Arrow signifies adds modification, T bar signifies removes modification. Therefore, for example, removing an inhibitory modification generates a green T bar, as the effect on the target is activation. Orange factors are anti-longevity, blue are pro-longevity.