Fig. 4.

Low doses of Dox/CpG MPs are more efficient at reducing A20 tumor burdens. Nine million A20 tumor cells were injected subcutaneously in the right and left flanks of BALB/c mice. After 10 days, mice received PBS as control or Dox/CpG MPs (2 or 10 μg Dox; 4:1 loading) in the left tumor and six intraperitoneal doses of anti-CTLA-4 (50 μg) given every 3–4 days. Mice were monitored for tumor growth of both injected and distant tumors and survival. Tumor areas are mean ± SEM