Table I.
Parameter Estimates (Est) and Percentage Relative Standard Errors (SE%) Obtained by Fitting the Empirical Model to (a) Scintigraphy (Scin), LDOPA and Paracetamol (PCM) Plasma Concentration Data (b) Scin and LDOPA and (c) LDOPA Only
| Parameter | Scin LDOPA PCM | Scin LDOPA | LDOPA | |
|---|---|---|---|---|
| Est (SE%) | Est (SE%) | Est (SE%) | ||
| Gastric Emptying | kg1 (min‐ 1) | 0.100 (9.8) | 0.0958 (8.1) | 0.142 (401) |
| kg2 (min‐ 1) | 0.00889 (23) | 0.00894 (33) | 0.00626 (180) | |
| tend (min) | 10.4 (12) | 11.0 (12) | 9.06 (38) | |
| tlag (min) | 53.1 (2.4) | 52.9 (2.4) | 49.8 (2.7) | |
| LDOPA profile | ka (min‐ 1) | 7.50 (1600) | 290. (1.1E6) | 0.850 (490) |
| k (min‐ 1) | 0.0498 (18) | 0.0507 (31) | 0.0453 (44) | |
| k 12 (min‐ 1) | 0.0285 (21) | 0.0290 (39) | 0.0268 (74) | |
| k 21 (min‐ 1) | 0.0109 (39) | 0.0111 (47) | 0.0149 (37) | |
| v (L) | 15.9 (15) | 15.6 (24) | 18.1 (34) | |
| Paracetamol profile | ka (min‐ 1) | 2580 (7.6E5) | – | – |
| k (min‐ 1) | 0.0170 (44) | – | – | |
| k 12 (min‐ 1) | 0.0768 (26) | – | – | |
| k 21 (min‐ 1) | 0.0163 (43) | – | – | |
| v (L) | 14.4 (26) | – | – |