Table II.
Parameter Estimates (Est) and Percentage Relative Standard Errors (SE%) Obtained by Fitting the Semi-mechanistic Model to (a) Scintigraphy (Scin), LDOPA and Paracetamol (PCM) Plasma Concentration Data (b) Scin and LDOPA and (c) LDOPA Only
| Parameter | Scin LDOPA PCM | Scin LDOPA | LDOPA | |
|---|---|---|---|---|
| Est (SE%) | Est (SE%) | Est (SE%) | ||
| Gastric emptying | kg0 (min‐ 1) | 0.0116 (12) | 0.0921 (10) | 0.0938 (200) |
| emax | 0.927 (2.3) | 0.900 (4.7) | 0.896 (76) | |
| ec50 (μg/L) | 936 (5.6) | 997 (9.4) | 1010 (80) | |
| gamma | 90.1 (270) | 69.4 (240) | 77.6 (940) | |
| ke0 (min‐ 1) | 0.0605 (16) | 0.0512 (41) | 0.0514 (520) | |
| LDOPA profile | ka (min‐ 1) | 1.06 (88) | 3.05 (1100) | 3.08 (9800) |
| k (min‐ 1) | 0.0409 (31) | 0.0403 (46) | 0.0405 (310) | |
| k 12 (min‐ 1) | 0.0287 (24) | 0.0300 (31) | 0.0305 (290) | |
| k 21 (min‐ 1) | 0.00623 (64) | 0.00669 (79) | 0.00681 (240) | |
| v (L) | 16.8 (15) | 17.0 (25) | 17.1 (230) | |
| Paracetamol profile | ka (min‐ 1) | 7.65 (2500) | – | – |
| k (min‐ 1) | 0.0179 (43) | – | – | |
| k 12 (min‐ 1) | 0.0795 (26) | – | – | |
| k 21 (min‐ 1) | 0.0162 (50) | – | – | |
| v (L) | 13.7 (34) | – | – |