Table III.
Parameter Estimates (Est) and Percentage Relative Standard Error (SE%) Obtained by Fitting the Semi-mechanistic Model to LDOPA Plasma Concentration Data for Two Individuals
| Parameter | ID 1 | ID 2 | |
|---|---|---|---|
| Est (SE%) | Est (SE%) | ||
| Gastric Emptying | kg0 (min‐ 1) | 0.0492 (92) | 0.0248 (370) |
| emax | 1.00 (37) | 0.951 (150) | |
| ec50 (μg/L) | 984 (14) | 701 (55) | |
| gamma | 80.0 (840) | 39.9 (2.1E3) | |
| k e0 (min‐ 1) | 0.0356 (85) | 0.0258 (310) | |
| LDOPA profile | ka (min‐ 1) | 0.126 (260) | 0.0584 (3.9E4) |
| k (min‐ 1) | 0.0520 (260) | 0.0168 (4.6E4) | |
| k 12 (min‐ 1) | 0.0250 (280) | 0.0417 (3.9E4) | |
| k 21 (min‐ 1) | 0.00554 (38) | 0.000335 (6.6E3) | |
| v (L) | 22.6 (260) | 25.0 (3.9E4) |