Table I.
Physicochemical Properties of Liposomal Formulations
| Z ave diameter (nm) | PDI | ZP (mV) | OVA24 LE (%) | Poly(I:C) LE (%) | |
|---|---|---|---|---|---|
| Empty liposomes | 142 ± 5 | 0.15 ± 0.02 | 34 ± 4 | NA | NA |
| OVA24-loaded Liposomes | 130 ± 5* | 0.12 ± 0.02 | 25 ± 3* | 40 ± 8 | NA |
| OVA24/poly(I:C)-loaded liposomes | 148 ± 8 | 0.16 ± 0.05 | 28 ± 3 | 38 ± 5 | 50 ± 4 |
Data are averages ± SD of at least five independent batches
Z ave average particle diameter in nanometres, PDI polydispersity index, ZP zeta-potential, LE loading efficiency, NA not applicable
*p < 0.05 (size and ZP are significantly different from empty liposomes, evaluated by one-way ANOVA with Tukey’s test)