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Strategies to enhance peptide stability: GLP-1 peptide has a half-life of 1–2 min. Modification of labile amino acids resulted in exenatide having enhanced serum stability, and clearance shifted from proteolysis to renal clearance, half-life 26 min. Addition of palmitoyl chain (C16 fatty acid) to GLP-1 formed liraglutide with decreased proteolysis and renal clearance, half-life 8 h IV, 11–15 h SC enabled QD dosing
