Table I.
Parameter values used in the simulation of the base scenario (scenario 1)
| Parameter | Typical value | Interindividual variability (%)a | Explanation |
|---|---|---|---|
| BL | 50 | 30 | Efficacy variable at baseline |
| PLmax (%) | 20 | 120 | Maximum placebo effect |
| k pl (h−1) | 0.25 | 44 | Rate constant for onset of placebo effect |
| EC50 (units/L) | 20 | 122 | Concentration leading to 50% of maximum efficacy |
| CL (L/h) | 10 | 30 | Clearance |
| V (L) | 10 | 30 | Volume of distribution |
| h 0 (h−1) | 0.01 | - | Baseline hazard |
| h e | 0.05 | - | Parameter for relationship between hazard and effect variable |
| σ (effect units) | 7.5 | - | Additive residual variability |
aInterindividual variability expressed as coefficient of variation