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. 2014 Oct 3;14:535. doi: 10.1186/1471-2334-14-535

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© Mustafa et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Human lymph nodes tissue infected with M. tuberculosis showing the staining pattern of mycobacterial secreted antigens in the necrotic granulomas as detected by immunohistochemical staining. Right column shows higher magnification of the marked areas in the corresponding pictures. There is a differential staining of various secreted antigens. MPT64 is detected in epithelioid cells and multinucleated giant cells, while the necrotic centres do not contain this antigen. MPT59 (Ag85B) and MPT63 were detected in few cases and were located only in the necrotic centres in these cases. Granuloma cells were not stained by these antibodies. The majority of the lymphadenitis granulomas were not stained for secreted antigens. NC = necrotic centres.