Table 3.

Top-ranked risk SNPs (p<α) for alcohol dependence in SERINC2 in European Americans

			MAF		European-Americans
SNP	Gene	Location	Cases	Controls	OR	p-value	q-value
rs34278290◄	SERINC2	Intron 2	0.061	0.044	1.52	5.9×10−4	0.0043
rs2275437	SERINC2	Exon 7	0.057	0.039	1.60	2.0×10−4	0.0025
rs35961897	SERINC2	Intron 10	0.059	0.038	1.69	4.1×10−5	0.0008
rs4949405	SERINC2	Intron 12	0.050	0.030	1.79	4.2×10−5	0.0008
rs7417775●#	SERINC2	3’ UTR	0.033	0.021	1.79	5.3×10−4	0.0043

^◄, located in transcription factor binding sites;

^●, affacting miRNA binding site activity;

^#, having significant cis-acting regulatory effects on SERINC2 mRNA expression (p=0.024).