. Author manuscript; available in PMC: 2015 Jan 8.

Published in final edited form as: Obesity (Silver Spring). 2012 Mar 29;20(10):2083–2092. doi: 10.1038/oby.2012.74

Table 2. a. Chromosomal regions linked to MS with LOD scores ≥ 1.2 based on multipoint linkage analyses.

Marker region	Distance from p-ter (cM)^a	Chromosomal location	Maximum LOD^b
D2S1360	38	2p24.2	1.2
D2S1328	133	2q14.3	1.3
D5S2845	36	5p14.3	1.5
D7S2212-D7S821/ GATA5D08	95-109	7q21.11-7q21.3	3.6
D8S1136/GATA41A01	82	8q13.1	2.6
D11S1999	17	11p15.4	2.3
D13S1265-D13S285	99-111	13q33.3-13q34	1.6
^aMarshfield data (Kosambi cM)
^bMS adjusted for covariate effects of age

b. Evidence for linkage of the five dichotomous MS risk factors as defined by NCEP/ATPIII criteria and the corresponding quantitative traits on chromosome 7q
Traits (Dichotomous; Quantitative)	Distance from p-ter (cM)^a	Maximum LOD^b
Abdominal Obesity; WC	95-109	1.45; 1.65
High Triglycerides; TG	95-109	0.76; 0.19
Low HDL-C; HDL-C	95-109	1.12; 1.36
High fasting glucose; FG	95-109	0.85; 0.22
High blood pressure; SBP and DBP	95-109	0.43; 0.05 and 0.54

Marshfield data (Kosambi cM)

all dichotomous traits adjusted for covariate effects of age as in the case of original linkage analysis (Table 2a); quantitative traits were adjusted for age and sex terms as well as for medication status for TG, HDL-C, FG, SBP and DBP